MT-II (Melanotan II) (10mg)

What is Melanotan II (10mg)? Melanotan II (MT-II) is a synthetic cyclic peptide modeled on the natural hormone α-melanocyte-stimulating hormone (α-MSH). By acting as a non-selective agonist at melanocortin receptors MC₁R, MC₃R, MC₄R, and MC₅R, MT-II mimics the biological activity of α-MSH. Its receptor interactions make it a widely studied compound in the fields of pigmentation research, metabolic regulation, neuroendocrine activity, and cellular signaling pathways. Chemical Structure of MT-II Type: Synthetic heptapeptide analogue Sequence: Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂ Stability: Features a lactam bridge between Asp and Lys, producing a cyclic structure that enhances binding affinity and resistance to enzymatic degradation Molecular formula: C₅₀H₆₉N₁₅O₉ Molecular weight: ~1,024.2 Da Registry: Listed in PubChem under CID 92432 The cyclic backbone provides greater structural integrity compared to linear peptides, extending activity and improving receptor selectivity in research models. Research Applications of MT-II Pigmentation DynamicsMT-II activates MC₁R receptors, stimulating eumelanin production and influencing pigmentation responses in experimental settings. Metabolism & Appetite StudiesInteraction with MC₃R and MC₄R has made MT-II a target for studies involving energy homeostasis, satiety, and nutrient balance. Cellular and Tumor BiologyLaboratory models indicate that MT-II may influence cell signaling pathways such as PTEN and NF-κB, with effects on melanoma cell behavior. Neuroendocrine & Behavioral PathwaysThrough MC₄R activity, MT-II has been investigated for its role in neuroendocrine function and behavioral modulation, making it of interest in neuroscience research. Citations PubChem Compound Summary for Melanotan II (CID 92432): sequence Ac‑Nle‑cyclo[Asp‑His‑D‑Phe‑Arg‑Trp‑Lys]‑NH₂; molecular data. Overview of Melanotan II (MT‑II) Dhillo WS, et al. “Melanocortin pathways and pigmentation mechanisms.” Peptides. 2009;30(3):567–575. PMID: 19027014. Overview of Melanotan II (MT‑II) Caruso C, et al. “Melanotan II modulates melanoma tumor cell growth via PTEN signaling.” Int J Mol Sci. 2020;21(2):681. PMID: 32015140. Overview of Melanotan II (MT‑II) Grill HJ, et al. “Melanocortin-4 receptor regulation of energy homeostasis and appetite suppression.” Endocrinology. 2003;144(1):21–30. PMID: 12488328. Overview of Melanotan II (MT‑II) Wessells H, et al. “Melanotan II: neuroendocrine effects on sexual behavior.” J Urol. 2000;164(2):386–393. PMID: 10893598. Overview of Melanotan II (MT‑II)